CATSPERB

cation channel sperm associated auxiliary subunit beta

Ensembl:
ENSG00000133962, ENSG00000274338
UniProt:
Q9H7T0
OMIM:
611169
Synonyms:
C14ORF161, FLJ14298

Cilia effects upon perturbation of CATSPERB

Ciliogenesis screen results (4 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Failler/Valderrama et al. 2021 (siRNA) [siRNA]: Negative Regulator (Ciliogenesis Candidate) PMID:33206585
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-2.61) PMID:41160700

Subcellular localization

flagella

Functional category

  • Reproduction & sperm
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Like the CatSper ion channel subunits, CatSperβ was restricted to testis and localized to the principal piece of the sperm tail.