CATSPERZ

catsper channel auxiliary subunit zeta

Ensembl:
ENSG00000219435
UniProt:
Q9NTU4
OMIM:
617511
Synonyms:
C11ORF20, DKFZP566E164, TEX40

Cilia effects upon perturbation of CATSPERZ

Phenotypes

Mouse phenotype:
decreased grip strength, impaired righting response, mydriasis, limb grasping, decreased bone mineral density, decreased bone mineral content
Mouse ciliopathy phenotype:
increased heart weight

Subcellular localization

flagella

Functional category

  • Actin & cytoskeleton regulation
  • T cell biology
  • Reproduction & sperm
  • Protein processing & maturation
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

In both human and mouse sperm cells, CatSper ε and ζ proteins are localized to the principal piece of the tails (28226241).

Model organism evidence

Mus musculus (1 reference)

Normally distributed in linear quadrilateral nanodomains along the flagellum, the complex lacking CatSperζ is disrupted at ~0.8 μm intervals along the flagellum.

PMIDs: 28226241