CBL

Cilia effects upon perturbation of CBL

Ciliogenesis screen results (4 screens)

• Kim2016: Not Reported
• Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.90) PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:

prolonged pr interval, preweaning lethality, incomplete penetrance

Mouse ciliopathy phenotype:

thick ventricular wall

Subcellular localization

cilia, cytosol, endosome, nucleus, transition zone

Functional category

• Ciliary assembly/disassembly
• Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
• Actin & cytoskeleton regulation
• T cell biology
• Viral interactions
• Signaling (Hedgehog, GPCRs, ion channels)
• Transition zone

Function

Cbl localized at the base and the proximal part of the primary cilium as well as in the Golgi complex in unstimulated NIH3T3 cells (29237719).