CCDC13

coiled-coil domain containing 13

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000244607
UniProt:: Q8IYE1
Synonyms:: FLJ25467

Ciliogenesis screen results (2 screens)

Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-10.63) PMID:26167766

Phenotypes

Mouse phenotype:: preweaning lethality, incomplete penetrance

Subcellular localization

basal body

References: PMID:41005307, PMID:24816561

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation

Function

Required for primary cilia formation and promotes the localisation of protein BBS4 to both centriolar satellites. Promotes genome stability and maintaining a stable microtubule array(24816561).

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