CCDC13

coiled-coil domain containing 13

Ensembl:: ENSG00000244607
UniProt:: Q8IYE1
Synonyms:: FLJ25467

Cilia effects upon perturbation of CCDC13

Ciliogenesis screen results (2 screens)

Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-10.63) PMID:26167766

Phenotypes

Mouse phenotype:: preweaning lethality, incomplete penetrance

Subcellular localization

basal body

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation

Function

Required for primary cilia formation and promotes the localisation of protein BBS4 to both centriolar satellites. Promotes genome stability and maintaining a stable microtubule array(24816561).

Model organism evidence

Drosophila (1 reference)

We show that Ccdc13 localizes along the central MTs and is essential for its formation in sperm flagella, with its deleti

PMIDs: 40492112

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