CCDC146

coiled-coil domain containing 146

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000135205
UniProt:
Q8IYE0
OMIM:
619829
Synonyms:
KIAA1505, MBO2

Ciliogenesis screen results (2 screens)

  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-3.86) PMID:41160700

Ciliopathy associations

  • Male Infertility

References: PMID:39245651

Subcellular localization

basal body

References: PMID:25074808

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Reproduction & sperm
  • Cell migration & adhesion

Function

CCDC113, CCDC96, C4orf47, CCDC38, C7orf31, CCDC146, CCDC81 and CCDC116 as centrosome-associated proteins(25074808).