CCDC146

coiled-coil domain containing 146

Ensembl:
ENSG00000135205
UniProt:
Q8IYE0
OMIM:
619829
Synonyms:
KIAA1505, MBO2

Cilia effects upon perturbation of CCDC146

Ciliogenesis screen results (2 screens)

  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-3.86) PMID:41160700

Phenotypes

Mouse ciliopathy phenotype:
cataract

Ciliopathy associations

  • Male Infertility

Subcellular localization

basal body

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • T cell biology
  • Reproduction & sperm
  • Cell migration & adhesion

Function

CCDC113, CCDC96, C4orf47, CCDC38, C7orf31, CCDC146, CCDC81 and CCDC116 as centrosome-associated proteins(25074808).

Model organism evidence

Mus musculus (1 reference)

CCDC146 is required for sperm flagellum biogenesis and male fertility in mice.

PMIDs: 38038747