CCDC15

coiled-coil domain containing 15

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000149548
UniProt:
Q0P6D6
Synonyms:
FLJ13215

Cilia effects upon perturbation of CCDC15

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

basal body, centrosome

References: PMID:37934472

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

CCDC15 depletion affects centriole length and integrity, leading to defective cilium formation, maintenance, and response to Hedgehog signaling(37934472). While control cells ciliated at 70.1% ± 6.4, CCDC15-depleted cells ciliated at 45.6% ± 0.8 . As quantified from immunofluorescence images and assessed by U-ExM, the cilia that formed in CCDC15-depleted cells were significantly shorter in length (37934472).