CCDC170

coiled-coil domain containing 170

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000120262
UniProt:: Q8IYT3
Synonyms:: BA282P11.1, C6ORF97, FLJ23305

Ciliogenesis screen results (1 screens)

Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:: abnormal vocalization

Subcellular localization

cilia, ciliary tip, axoneme

References: PMID:41410385, PMID:42010243, PMID:38956598

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation

Function

Gene sets (GS) associated with ependymal development, ciliary function and the immune system were specially modified qPCR confirmed reduced expression in the KO mice genes and these genes associated with ciliary assembly (Cfap43, Cfap69 and Ccdc170)( 38956598).

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