CCDC172

Cilia effects upon perturbation of CCDC172

Ciliogenesis screen results (1 screen)

• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

flagella

Functional category

• Reproduction & sperm

Function

By yeast two-hybrid screening, flagellar proteins that could interact with TEKT2 , which resulted in the isolation of novel two genes from the mouse testis library, referred as a TEKT2-binding protein 1 (TEKT2BP1) and -protein 2 (TEKT2BP2) isolated.RT-PCR analysis indicated that TEKT2BP1, which is registered as a coiled-coil domain-containing protein 172 (Ccdc172), was predominantly expressed in rat testis and that its expression was increased after 3 weeks of postnatal development. Immunocytochemical studies discovered that TEKT2BP1 localized in the middle piece of rat spermatozoa, predominantly concentrated at the mitochondria sheath of the flagella(PMID: 24394471).

Model organism evidence