CCDC33
coiled-coil domain containing 33
- Ensembl:
- ENSG00000288407, ENSG00000140481
- UniProt:
- Q8N5R6
- OMIM:
- 618525
- Synonyms:
- CC2D3, CT61, FLJ32855
Cilia effects upon perturbation of CCDC33
- Cilia number / % ciliated:
- No effect
- Loss-of-function effect:
- Decrease
Ciliogenesis screen results (2 screens)
- Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Phenotypes
- Mouse phenotype:
- increased lung weight
- Mouse ciliopathy phenotype:
- short tibia
Subcellular localization
cilia
Functional category
- Ciliary assembly/disassembly
Function
Fam166b and Ccdc33 were found to be strongly restricted to the ciliary axoneme (29180514). CCDC33 occupies the extreme distal tip of vertebrate MCC cilia; independently required for normal cilia length regulation. Loss causes distinct pattern of defective cilia beating.
Model organism evidence
Mus musculus (1 reference)
A protein complex in the extreme distal tip of vertebrate motile cilia controls their organization, length, and function.
PMIDs: 40027778