CCDC33

coiled-coil domain containing 33

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000288407
UniProt:: Q8N5R6
OMIM:: 618525
Synonyms:: CC2D3, CT61, FLJ32855

Cilia effects upon perturbation of CCDC33

Cilia number / % ciliated:: No effect
Loss-of-function effect:: Decrease

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:: increased lung weight

Subcellular localization

cilia

References: PMID:29180514

Functional category

Ciliary assembly/disassembly

Function

Fam166b and Ccdc33 were found to be strongly restricted to the ciliary axoneme (29180514). CCDC33 occupies the extreme distal tip of vertebrate MCC cilia; independently required for normal cilia length regulation. Loss causes distinct pattern of defective cilia beating.

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