CCDC42
coiled-coil domain containing 42
- Ensembl:
- ENSG00000161973
- UniProt:
- Q96M95
- Synonyms:
- CCDC42A, FLJ32734
Cilia effects upon perturbation of CCDC42
Ciliogenesis screen results (3 screens)
- Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
- Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-2.15) PMID:41160700
Subcellular localization
basal body
Functional category
- Ciliary assembly/disassembly
- Actin & cytoskeleton regulation
- Reproduction & sperm
Function
CCDC42 is expressed in spermatids and localizes to the manchette, the connecting piece and the tail and also expressed in somatic cells in which it localizes to the centrosome(31475146).
Model organism evidence
Mus musculus (2 references)
Deficiency of coiled-coil domain-containing (CCDC) 42 (CCDC42) is specifically associated with malformation of mouse sperm flagella.
Here, we provide data indicating that mutations in the gene Coiled-coil domain containing 42 (Ccdc42) is associated with malformation of the mouse sperm flagella.