CCDC42

coiled-coil domain containing 42

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000161973
UniProt:: Q96M95
Synonyms:: CCDC42A, FLJ32734

Ciliogenesis screen results (3 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-2.15) PMID:41160700

Subcellular localization

basal body

References: PMID:31475146

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation
Reproduction & sperm

Function

CCDC42 is expressed in spermatids and localizes to the manchette, the connecting piece and the tail and also expressed in somatic cells in which it localizes to the centrosome(31475146).

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