CCDC6

coiled-coil domain containing 6

Ensembl:
ENSG00000108091
UniProt:
Q16204
OMIM:
601985
Synonyms:
D10S170, H4, PTC, PTC1, TPC

Cilia effects upon perturbation of CCDC6

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
preweaning lethality, complete penetrance

Subcellular localization

cilia associated gene

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation

Function

Platelet-derived growth factor A (PDGFA) and coiled-coil domain-containing protein 6 (CCDC6) are two interactions that link Cluap1 to ciliogenesis and cancer development ( 29615496).