CCDC61

coiled-coil domain containing 61

Ensembl:
ENSG00000104983
UniProt:
Q9Y6R9
OMIM:
620676
Synonyms:
HVFL3, VFL3

Cilia effects upon perturbation of CCDC61

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-7.19) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

basal body, centrosome

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation

Function

CCDC61 is a paralog of SAS6, XRCC4, XLF, and PAXX, CCDC61 binds to mainly via its coiled-coil domain, and associates with basal bodies and plays a role in ciliogenesis(32375023).

Model organism evidence

Xenopus (1 reference)

Lrrcc1 and Ccdc61 are conserved effectors of multiciliated cell function.

PMIDs: 35067717