CCDC63

coiled-coil domain containing 63

Ensembl:
ENSG00000173093
UniProt:
Q8NA47
OMIM:
617969
Synonyms:
FLJ35843, ODA5

Cilia effects upon perturbation of CCDC63

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.76) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

cilia

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Reproduction & sperm

Function

In Tetrahyme , loss of either FAP61 or FAP251 reduces cell swimming and affects the ciliary waveform and that RS3 is either missing or incomplete, the CSC proteins FAP61 and FAP251 build the basal substructures of radial spoke 3 in cilia(25694453).