CCDC81

coiled-coil domain containing 81

Ensembl:
ENSG00000149201
UniProt:
Q6ZN84
Synonyms:
FLJ16339, FLJ23514

Cilia effects upon perturbation of CCDC81

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (1 screen)

  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

basal body

Functional category

  • Ciliary assembly/disassembly

Function

CCDC113, CCDC96, C4orf47, CCDC38, C7orf31, CCDC146, CCDC81 and CCDC116 as centrosome-associated proteins(25074808). Silencing of CCDC81 resulted in a decrease in both the frequency and length of primary cilia (PMID: 40751511).

Model organism evidence

Mus musculus (1 reference)

Centrosome Protein CCDC81 Promotes Ciliogenesis.

PMIDs: 40751511