?

Subcellular localization

Ciliary associated gene, Nuclear speckles, Cell Junctions

Functional category

• Cardiac & muscle development
• Metabolism

Function

In this study in Ccdc85c KO rats, we performed α-tubulin IHC and scanning electron microscopy to know the fate of ependymal cilia at P26. In the KO rat, only round cell bodies remained on the ventricular surface upon the loss of ependymal cilia. Thus, it is conceivable to state that the Ccdc85c gene mutation causes variable degrees of loss of ependymal cilia and also contributes to the proliferation of smooth muscle-like immature cells in the ventricular wall of KO rats(39825670). Proper differentiation of ciliated ependymal cells may be hampered in the Ccdc85c KO rat due to ependymal cell maldevelopment, which could be one of the primary modulators of hydrocephalus(37271245).