CCDC88A
coiled-coil domain containing 88A
- Ensembl:
- ENSG00000115355
- UniProt:
- Q3V6T2
- OMIM:
- 609736
- Synonyms:
- APE, FLJ10392, GIV, GRDN, HKRP1
Cilia effects upon perturbation of CCDC88A
Ciliogenesis screen results (3 screens)
- Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
- Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-2.98) PMID:41160700
Subcellular localization
basal body, cytosol, endosome
Functional category
- Ciliary assembly/disassembly
- Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
- Actin & cytoskeleton regulation
- Protein processing & maturation
- Signaling (Hedgehog, GPCRs, ion channels)
Function
Conserved sig ling and scaffolding protein Girdin localizes to the proximal regions of centrioles and regulates BB positioning and ciliogenesis in Caenorhabditis elegans sensory neurons and human RPE-1 cells. Girdin depletion alters localization of the intercentriolar linker and ciliary rootlet component rootletin, and rootletin knockdown in RPE-1 cells mimics Girdin-dependent phenotypes. C. elegans Girdin also regulates localization of the apical junction component AJM-1, suggesting that in nematodes Girdin may position BBs via rootletin- and AJM-1-dependent anchoring to the cytoskeleton and plasma membrane, respectively(27623382).