CCDC89

coiled-coil domain containing 89

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000179071
UniProt:: Q8N998
Synonyms:: FLJ38159

Ciliogenesis screen results (1 screens)

Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Ciliopathy associations

Male Infertility

Subcellular localization

cilia, nucleoplasm

References: PMID:40591933

Functional category

Reproduction & sperm

Function

Super-resolution imaging reveals that CCDC89 localizes to the axonemal lumen in motile cilia of mouse ependymal multiciliated cells(PMID: 41074672). The presence of CCDC89 is required for normal sperm motility and therefore optimal male fertility in mice, while CCDC89 variants affected spermatogenesis in both mice and humans(PMID: 40591933).

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