CCDC92

coiled-coil domain containing 92

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000275035
UniProt:: Q53HC0
Synonyms:: FLJ22471

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-14.63) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:: preweaning lethality, incomplete penetrance, increased bone mineral density, decreased brain weight, decreased grip strength, increased blood urea nitrogen level, decreased circulating cholesterol level, increased circulating serum albumin level

Subcellular localization

centrosome, cilia

References: PMID:25297623

Functional category

Ciliary assembly/disassembly
Trafficking (BBSome, small GTPases, vesicular transport, ATPases)

Function

TTBK2 directly phosphorylates CEP83, CEP89, Rabin8, CCDC92, and DVL3 (25297623).

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