CCHCR1

coiled-coil alpha-helical rod protein 1

Ensembl:
ENSG00000204536
UniProt:
Q8TD31
OMIM:
605310
Synonyms:
C6ORF18, HCR

Cilia effects upon perturbation of CCHCR1

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.46) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: Joubert Candidate / Ciliogenesis Defect (robust z=-2.13, ciliated=21.3%) PMID:26595381

Phenotypes

Mouse phenotype:
hyperactivity, increased vertical activity

Subcellular localization

centrosome, cilia associated gene, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation

Function

CCHCR1 recruits P-body proteins to the centrosome through interacting with EDC4 via its N-terminal coiled-coil domain. Depletion of either CCHCR1 or P-body components EDC4 and DEAD-Box Helicase 6 (DDX6) impairs ciliogenesis(PMID: 40883668).