CCL2

C-C motif chemokine ligand 2

Ensembl:
ENSG00000108691
UniProt:
P13500
OMIM:
158105
Synonyms:
GDCF-2, HC11, MCAF, MCP-1, MCP1

Cilia effects upon perturbation of CCL2

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.46) PMID:26167766
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia associated gene

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • T cell biology
  • Viral interactions
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Loss of LKB1 or PC1 increases CCL2 expression and peritubular macrophage numbers and promotes ciliopathy phenotypes. The Polycystic Kidney Disase (PKD) phenotype seen upon PKD1 depletion is ameliorated in the absence of cilia or tubular CCL2 ( 29925518).

Model organism evidence

Mus musculus (1 reference)

Renal ciliopathies are the leading cause of inherited kidney failure.

PMIDs: 35043953