CCL2

C-C motif chemokine ligand 2

Tier: Cilia-Associated Genes

Ensembl:: ENSG00000108691
UniProt:: P13500
OMIM:: 158105
Synonyms:: GDCF-2, HC11, MCAF, MCP-1, MCP1, MGC9434, SCYA2, SMC-CF

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.46) PMID:26167766
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

No ciliary localization reported (cilia-associated gene).

References: PMID:29925518

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation
Viral interactions
Cell migration & adhesion
Signaling (Hedgehog, GPCRs, ion channels)

Function

Loss of LKB1 or PC1 increases CCL2 expression and peritubular macrophage numbers and promotes ciliopathy phenotypes. The Polycystic Kidney Disase (PKD) phenotype seen upon PKD1 depletion is ameliorated in the absence of cilia or tubular CCL2 ( 29925518). In preadipocytes CCL2 engages cilium-localized CCR2 to initiate adipogenesis via ERK (PMID 42893979).

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