CCN2

cellular communication network factor 2

Ensembl:: ENSG00000118523
UniProt:: P29279
OMIM:: 121009
Synonyms:: CTGF, IGFBP8

Cilia effects upon perturbation of CCN2

Subcellular localization

cilia associated gene

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation
Signaling (Hedgehog, GPCRs, ion channels)
ECM & connective tissue
Transcription regulation

Function

PTH1R localized to the primary cilium and this ciliary localization enhances parathyroid hormone (PTH) sig ling, leading to the transcription of integrin αvβ6. Subsequently, this activates the transforming growth factor-beta (TGF-β) pathway, which induces CCN2 expression. CCN2 then contributes to extracellular matrix production, aiding in disc homeostasis and regeneration ( 30038820).

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