CCN2

cellular communication network factor 2

Tier: Cilia-Associated Genes

Ensembl:: ENSG00000118523
UniProt:: P29279
OMIM:: 121009
Synonyms:: CTGF, IGFBP8

Subcellular localization

No ciliary localization reported (cilia-associated gene).

References: PMID:30038820

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation
Signaling (Hedgehog, GPCRs, ion channels)
ECM & connective tissue
Transcription regulation

Function

PTH1R localized to the primary cilium and this ciliary localization enhances parathyroid hormone (PTH) signaling, leading to the transcription of integrin αvβ6. Subsequently, this activates the transforming growth factor-beta (TGF-β) pathway, which induces CCN2 expression. CCN2 then contributes to extracellular matrix production, aiding in disc homeostasis and regeneration ( 30038820).

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