CCND2

Cilia effects upon perturbation of CCND2

Ciliogenesis screen results (4 screens)

• Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.85) PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
• Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-3.70) PMID:41160700

Phenotypes

Mouse phenotype:

increased circulating glucose level, trunk curl, decreased total body fat amount, increased fasting circulating glucose level, increased mean corpuscular volume, increased grip strength, impaired glucose tolerance, increased lean body mass, increased circulating alkaline phosphatase level, increased circulating phosphate level, hyperactivity, increased circulating iron level

Mouse ciliopathy phenotype:

small testis, abnormal cranium morphology, abnormal spine curvature

Human ciliopathy phenotype:

megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3; Megalencephaly - polymicrogyria - postaxial polydactyly - hydrocephalus

Subcellular localization

cilia, cytosol, nucleus

Functional category

• Ciliary assembly/disassembly
• Transcription regulation

Function

CCND2 has localized in cilia.