CCND2

cyclin D2

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000118971
UniProt:: P30279
OMIM:: 123833

Ciliogenesis screen results (4 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.85) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-3.70) PMID:41160700

Phenotypes

Mouse phenotype:: increased circulating glucose level, trunk curl, decreased total body fat amount, increased fasting circulating glucose level, increased mean corpuscular volume, increased grip strength, impaired glucose tolerance, increased lean body mass, increased circulating alkaline phosphatase level, increased circulating phosphate level, hyperactivity, increased circulating iron level
Human ciliopathy phenotype:: megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3; Megalencephaly - polymicrogyria - postaxial polydactyly - hydrocephalus

Subcellular localization

cilia, cytosol, nucleus, ciliary tip

References: PMID:41005307

Functional category

Ciliary assembly/disassembly
Transcription regulation

Function

CCND2 has localized in cilia.

Note: Additional interactive sections (perturbation matrix visualization, phylogenetic conservation strip, protein complex network, STRING interactions) require JavaScript. Browse CiliaHub for the full experience.