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cyclin D3

Subcellular localization

basal body, Nucleoplasm, Cytosol

Function

Either endogenous or overexpressed CDK6, together with its cyclin partner cyclin D3, enrich at the cilia base in RPE-1 cells (Fig. 4, A, C, and E). Intriguingly, Cyclin D3, rather than CDK6 alone, interacts with ΔC2-FIP5 (Fig. 7 B), aligning with CDKs’ typical recruitment of substrates using cyclins. Importantly, the direct CDK6-mediated FIP5 phosphorylation was detected in in vitro kinase reaction assay, utilizing CAK-activated recombinant CDK6/cyclin D3 complex and anti-phosphoserine antibody (Fig. 7 C)(39636239).

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