CCNO

cyclin O

Ensembl:: ENSG00000152669
UniProt:: P22674
OMIM:: 607752
Synonyms:: CCNU, FLJ22422, UDG2, UNG2

Cilia effects upon perturbation of CCNO

Cilia number / % ciliated:: Decreased cilia number
Loss-of-function effect:: Shorter cilia

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse ciliopathy phenotype:: small kidney, abnormal kidney morphology
Human ciliopathy phenotype:: primary ciliary dyskinesia

Ciliopathy associations

Mucociliary Clearance Disorder
Primary Ciliary Dyskinesia

Subcellular localization

basal body, nucleus

Functional category

Ciliary assembly/disassembly
Protein processing & maturation
Transcription regulation

Function

Regulator of deuterosome formation and function for the amplification of centrioles in MCCs, for docking of centrioles to the apical cell membrane (25712475). Cyclin O is required to generate the basal bodies necessary for multiple cilia formation by promoting a process of centriole assembly and maturation (25048963) CCNO has role in transcriptional regulation of ciliary development (39094231).

Note: Additional interactive sections (perturbation matrix visualization, phylogenetic conservation strip, protein complex network, STRING interactions) require JavaScript. Browse CiliaHub for the full experience.