CCNO

Cilia effects upon perturbation of CCNO

Cilia number / % ciliated:

Decreased cilia number

Loss-of-function effect:

Shorter cilia

Ciliogenesis screen results (2 screens)

• Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Human ciliopathy phenotype:

primary ciliary dyskinesia

Ciliopathy associations

• Mucociliary Clearance Disorder
• Primary Ciliary Dyskinesia

References: PMID:24747639, PMID:25048963, PMID:26777464, PMID:24824133

Subcellular localization

basal body, nucleus

References: PMID:25712475, PMID:25048963, PMID:39094231

Functional category

• Ciliary assembly/disassembly
• Protein processing & maturation
• Transcription regulation

Function

Regulator of deuterosome formation and function for the amplification of centrioles in MCCs, for docking of centrioles to the apical cell membrane (25712475). Cyclin O is required to generate the basal bodies necessary for multiple cilia formation by promoting a process of centriole assembly and maturation (25048963) CCNO has role in transcriptional regulation of ciliary development (39094231).