CCNT1

Cilia effects upon perturbation of CCNT1

Ciliogenesis screen results (4 screens)

• Kim2016: Not Reported
• Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-7.49) PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, casTLE effect=-2.75) PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:

decreased circulating total protein level, decreased exploration in new environment, increased mean corpuscular volume, increased startle reflex, increased circulating alkaline phosphatase level, increased leukocyte cell number, increased mean corpuscular hemoglobin, decreased erythrocyte cell number

Mouse ciliopathy phenotype:

persistence of hyaloid vascular system

Subcellular localization

basal body, nucleus

Functional category

• Ciliary assembly/disassembly
• Viral interactions
• Signaling (Hedgehog, GPCRs, ion channels)
• Transcription regulation

Function

CCNT1 has localized in basal body.