CCR2

C-C motif chemokine receptor 2

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000121807
UniProt:: P41597
OMIM:: 601267
Synonyms:: CC-CKR-2, CKR2, MCP-1-R, CD192, FLJ78302, CMKBR2

Subcellular localization

cilia

Function

CCR2 localizes to the primary cilium of preadipocytes. Adipose stem cells transiently assemble cilia during commitment; high-fat diet raises CCL2, which acts on ciliary CCR2 to trigger ERK-dependent initiation of adipogenesis. Blocking cilium assembly or the CCL2/CCR2-ERK axis impairs adipogenesis (PMID 42893979).

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