CCT4

chaperonin containing TCP1 subunit 4

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000115484
OMIM:: 605142
Synonyms:: CCTD

Subcellular localization

flagella, Nucleoplasm, Cytosol

References: PMID:39743588

Functional category

Ciliary assembly/disassembly

Function

CCT4 components of the chaperonin-containing TCP1 (CCT/TRiC complex), associated mainly with sperm flagella assembly, not specific to cilia structure(39743588). Identified by cryo-EM as a component of the radial spoke-associated barrel in sperm flagella (Leung et al., 2025, Nature, PMID 39743588).

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