CCT8

chaperonin containing TCP1 subunit 8

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000156261
OMIM:: 617786
Synonyms:: C21ORF112, CCTQ, PRED71

Subcellular localization

flagella, Nucleoplasm, Cytosol, Connecting piece, Mid piece, Principal piece, End piece

References: PMID:33475699, PMID:39743588

Functional category

Ciliary assembly/disassembly

Function

CCT8 components of the chaperonin-containing TCP1 (CCT/TRiC complex), associated mainly with sperm flagella assembly, not specific to cilia structure(39743588). Identified by cryo-EM as a component of the radial spoke-associated barrel in sperm flagella (Leung et al., 2025, Nature, PMID 39743588).

Note: Additional interactive sections (perturbation matrix visualization, phylogenetic conservation strip, protein complex network, STRING interactions) require JavaScript. Browse CiliaHub for the full experience.