CD2AP

CD2 associated protein

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000198087
UniProt:: Q9Y5K6
OMIM:: 604241
Synonyms:: CMS

Cilia effects upon perturbation of CD2AP

Loss-of-function effect:: Longer cilia
Overexpression effect:: No effect

Ciliogenesis screen results (3 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-12.41) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:: decreased grip strength

Subcellular localization

cilia

References: PMID:36754282

Functional category

Ciliary assembly/disassembly
Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
Actin & cytoskeleton regulation
ECM & connective tissue

Function

CD2AP/CIN85 proteins regulate ciliary length by remodeling the actin network (36754282).EHBP1L1- and CD2AP/CIN85-depleted cells had elongated cilia. The aberrantly elongated cilia phenotype and the ciliary localization defect of CD2AP/CIN85 in EHBP1L1-depleted cells were rescued by the expression of WT EHBP1L1, although this was not observed in the CD2AP/CIN85-binding-deficient mutant, indicating that the EHBP1L1-CD2AP/CIN85 interaction is crucial for controlling ciliary length(36754282).

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