CD36

CD36 molecule (CD36 blood group)

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000135218
UniProt:
P16671
OMIM:
173510
Synonyms:
FAT, GP3B, GP4, GPIIIB, GPIV, SCARB3

Cilia effects upon perturbation of CD36

Cilia number / % ciliated:
Decreased cilia number

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.86) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, casTLE effect=-3.99) PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
enlarged spleen, hyperplasia, growth arrest, abnormal spleen morphology, decreased brain size, decreased fasting circulating glucose level, enlarged liver, decreased circulating triglyceride level, abnormal bone structure, abnormal skin morphology, hypospermia

Subcellular localization

cilia

References: PMID:27302750

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Metabolism
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

CD36 was both targeted to sensory cilia and capable of restoring, albeit only partially, responses to pheromone(27302750).