CD36

CD36 molecule (CD36 blood group)

Ensembl:
ENSG00000135218
UniProt:
P16671
OMIM:
173510
Synonyms:
FAT, GP3B, GP4, GPIIIB, GPIV

Cilia effects upon perturbation of CD36

Cilia number / % ciliated:
Decreased cilia number

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.86) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, casTLE effect=-3.99) PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
enlarged spleen, hyperplasia, growth arrest, abnormal spleen morphology, decreased brain size, decreased fasting circulating glucose level, enlarged liver, decreased circulating triglyceride level, abnormal bone structure, abnormal skin morphology, hypospermia
Mouse ciliopathy phenotype:
increased heart weight, abnormal vitreous body morphology, abnormal liver morphology, abnormal heart morphology, enlarged heart, eye hemorrhage, abnormal brain morphology, cataract

Subcellular localization

cilia

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Metabolism
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

CD36 was both targeted to sensory cilia and capable of restoring, albeit only partially, responses to pheromone(27302750).