CD44

CD44 molecule (IN blood group)

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000026508
UniProt:
P16070
OMIM:
107269
Synonyms:
CD44R, CDW44, CSPG8, ECM-III, H-CAM, HCELL, HERMES-1, HUTCH-1, HUTCH-I, IN, MC56, MDU2, MDU3, MIC4, PGP-1, PGP1

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-10.65) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia

References: PMID:32339903

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Cell migration & adhesion
  • ECM & connective tissue

Function

The primary cilium is linked to OPN signaling pathway and actin cytoskeleton pathway via CD44 and Cdc42. The primary cilium acts as an FAK regulation unit consisting of CD44 and ciliary integrinβ1 in MSCs(32339903).