CD79A

CD79a molecule

Ensembl:
ENSG00000105369
UniProt:
P11912
OMIM:
112205
Synonyms:
IG-ALPHA, IGA, IGALPHA, MB-1, MB1

Cilia effects upon perturbation of CD79A

Loss-of-function effect:
Longer cilia

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia associated gene

Functional category

  • Ciliary assembly/disassembly
  • T cell biology
  • Viral interactions
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Pre-cystic Cd79a-Tsc1 KO tubule cells display abnormal cilia elongation as well as defective PCP, resulting in alterations in both convergent extension (CE) and oriented cell division (OCD) ( 36627370).

Model organism evidence

Mus musculus (1 reference)

Defects in primary cilia and their signaling (eg, mTOR) underlie the pathogenesis.

PMIDs: 36627370