CD81
CD81 molecule
- Ensembl:
- ENSG00000110651
- UniProt:
- P60033
- OMIM:
- 186845
- Synonyms:
- S5.7, TAPA-1, TAPA1, TSPAN28
Cilia effects upon perturbation of CD81
Ciliogenesis screen results (3 screens)
- Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-12.24) PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
- Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
Subcellular localization
cilia, lysosomes
Functional category
- Ciliary assembly/disassembly
- Actin & cytoskeleton regulation
- T cell biology
- Viral interactions
- Cell migration & adhesion
- Signaling (Hedgehog, GPCRs, ion channels)
- Cardiac & muscle development
Function
CD81 and CD82 localized in cilia (26585297).
Model organism evidence
C. elegans (2 references)
Single-molecule tracking demonstrates that the tetraspanin TSP-6 enters and diffuses within the cilia and does it independently of IFT.
To maintain cilia composition, a tight regulation of cargo import and removal is achieved by the action of intra-flagellar transport (IFT).