CD9
CD9 molecule
- Ensembl:
- ENSG00000010278
- UniProt:
- P21926
- OMIM:
- 143030
- Synonyms:
- BA2, MIC3, MRP-1, P24, TSPAN29
Cilia effects upon perturbation of CD9
Ciliogenesis screen results (3 screens)
- Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
- Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
Phenotypes
- Mouse ciliopathy phenotype:
- increased heart weight
Subcellular localization
cilia
Functional category
- Ciliary assembly/disassembly
- Actin & cytoskeleton regulation
- Viral interactions
- Cell migration & adhesion
- Signaling (Hedgehog, GPCRs, ion channels)
- Cardiac & muscle development
Function
The extracellular vesicle (EV) marker TSP-6(an ortholog of mammalian CD9) localizes to the cilia region(34533135). The cells of the MCL on the IL side consisted of cluster of differentiation 9 (CD9)-positive stem/progenitor cells with or without motile cilia(35316373).
Model organism evidence
Mus musculus (1 reference)
Immunocytochemistry localized acid sphingomyelinase (ASM), a ceramide-generating enzyme, to ependymal cilia, suggesting these sites as a potential source of EVs.
PMIDs: 41959010
C. elegans (2 references)
Single-molecule tracking demonstrates that the tetraspanin TSP-6 enters and diffuses within the cilia and does it independently of IFT.
To maintain cilia composition, a tight regulation of cargo import and removal is achieved by the action of intra-flagellar transport (IFT).