CDC14A

Cilia effects upon perturbation of CDC14A

Cilia number / % ciliated:

Unknown

Loss-of-function effect:

Longer cilia

Overexpression effect:

Shorter cilia

Ciliogenesis screen results (4 screens)

• Kim2016: No effect
• Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-10.58) PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: Joubert Candidate / Ciliogenesis Defect (robust z=-2.55, ciliated=18.1%) PMID:26595381

Phenotypes

Mouse phenotype:

preweaning lethality, incomplete penetrance

Mouse ciliopathy phenotype:

cataract

Human ciliopathy phenotype:

hearing loss, autosomal recessive

Subcellular localization

basal body, centrosome, nucleus

Functional category

• Ciliary assembly/disassembly
• Actin & cytoskeleton regulation

Function

CDC14A activity in human and mouse is needed for the formation of the kinocilia in the organ of corti. Proline‐ directed phosphatase.CDC14A has the potential to counteract kinases that control the actinnetwork during ciliogenesis because it is associated with actin filaments and in addition plays a role in ciliogenesis. Contributes to cilia length control by regulating the actin nucleator Arp2 at the basalbody. CDC14A has additional functions in endocytosis and transport of myosin Va marked vesicles to the basal body (PMID: 30467237). Plays a role in mitotic timing, cytokinesis, meiosis, DNA repair, and transcriptionalrepression (PMID: 23027426).

Model organism evidence