CDC20B

cell division cycle 20B

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000164287
UniProt:: Q86Y33
OMIM:: 620335
Synonyms:: FLJ37927

Cilia effects upon perturbation of CDC20B

Cilia number / % ciliated:: Decreased cilia number

Ciliogenesis screen results (1 screens)

Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:: increased erythrocyte cell number, increased circulating triglyceride level, increased hematocrit

Subcellular localization

cilia

References: PMID:30405130

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation

Function

Specifically expressed in maturing multiciliated cells during the phase of centriole multiplication, it has been established the corresponding CDC20B protein as an essential regulator of centriole-deuterosome disengagement. Plays an essential and conserved role of in vertebrate multiciliogenesis. Function of promoting deuterosome assembly and/or activity, may contribute to activation of Separase. Involved in the production of centrioles (30405130).

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