CDC20B

Cilia effects upon perturbation of CDC20B

Cilia number / % ciliated:

Decreased cilia number

Ciliogenesis screen results (1 screen)

• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:

increased erythrocyte cell number, increased circulating triglyceride level, increased hematocrit

Subcellular localization

cilia

Functional category

• Ciliary assembly/disassembly
• Actin & cytoskeleton regulation

Function

Specifically expressed in maturing multiciliated cells during the phase of centriole multiplication, it has been established the corresponding CDC20B protein as an essential regulator of centriole-deuterosome disengagement. Plays an essential and conserved role of in vertebrate multiciliogenesis. Function of promoting deuterosome assembly and/or activity, may contribute to activation of Separase. Involved in the production of centrioles (30405130).

Model organism evidence