CDC42EP5

CDC42 effector protein 5

Ensembl:
ENSG00000273633, ENSG00000273622, ENSG00000167617, ENSG00000278444
UniProt:
Q6NZY7
OMIM:
609171
Synonyms:
BORG3, CEP5

Cilia effects upon perturbation of CDC42EP5

Cilia number / % ciliated:
Decreased cilia number

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.30) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Negative Regulator (Hh signaling, casTLE effect=3.47) PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
increased basophil cell number, abnormal coat/hair pigmentation, increased eosinophil cell number, decreased lean body mass

Subcellular localization

cilia

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation

Function

CDC42EP5 has localized in primary cilia. The gene is also known as Borg3 (40502696).