CDK1

cyclin dependent kinase 1

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000170312
UniProt:
P06493
OMIM:
116940
Synonyms:
CDC2, CDC28A

Cilia effects upon perturbation of CDK1

Loss-of-function effect:
Supernumerary cilia

Ciliogenesis screen results (4 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.20) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Increased Signaling (Negative Regulator) PMID:29459680
  • Basu et al. 2023 (siRNA) [siRNA]: Left-Right Asymmetry Defect (Z2MCilia=7.77, increased) PMID:37771269
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, neg_rank=754, lfc=-3.67) PMID:30270045

Subcellular localization

centrosome, cytosol, flagella, microtubules, nucleus

References: PMID:27326932, PMID:25613900, PMID:37771269

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Viral interactions
  • Protein processing & maturation
  • Cardiac & muscle development
  • Transcription regulation

Function

Cdk1 phosphorylates Sas-4 to initiate Polo/Plk1 recruitment to daughter basal bodys (27326932) and localized to flagella (25613900). Loss of MCM7 gene cause supernumerary cilia(PMID: 37771269).