CDK1

cyclin dependent kinase 1

Ensembl:
ENSG00000170312
UniProt:
P06493
OMIM:
116940
Synonyms:
CDC2, CDC28A

Cilia effects upon perturbation of CDK1

Loss-of-function effect:
Supernumerary cilia

Ciliogenesis screen results (4 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.20) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Increased Signaling (Negative Regulator) PMID:29459680
  • Basu et al. 2023 (siRNA) [siRNA]: Left-Right Asymmetry Defect (Z2MCilia=7.77, increased) PMID:37771269
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, neg_rank=754, lfc=-3.67) PMID:30270045

Subcellular localization

centrosome, cytosol, flagella, microtubules, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • T cell biology
  • Viral interactions
  • Protein processing & maturation
  • Cardiac & muscle development
  • Transcription regulation

Function

Cdk1 phosphorylates Sas-4 to initiate Polo/Plk1 recruitment to daughter basal bodys (27326932) and localized to flagella (25613900). Loss of MCM7 gene cause supernumerary cilia(PMID: 37771269).

Model organism evidence

Mus musculus (2 references)

Polycystins are expressed in the primary cilium, and disrupting cilia structure significantly slows ADPKD progression following inactivation of polycystins.

Calibrated mitotic oscillator drives motile ciliogenesis.

PMIDs: 33046531, 28982797