CDK10

cyclin dependent kinase 10

Ensembl:
ENSG00000185324
UniProt:
Q15131
OMIM:
603464
Synonyms:
PISSLRE

Cilia effects upon perturbation of CDK10

Cilia number / % ciliated:
Incrased cilia number
Loss-of-function effect:
Longer cilia

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.69) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Ciliopathy associations

  • STAR Syndrome

Subcellular localization

basal body

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation

Function

Interacts with Cyclin M (CycM), encoded by FAM58A to form an active protein ki se. CDK10/CycM is a key repressor of ciliogenesis through the regulation of RhoA and modulation of actin dy mics (27104747). Important for normal regulation of ciliogenesis (29130579). Knocking down CDK10 or CycM resulted in significant increase in the number of ciliated cells, abnormally long cilia and promotion of the maintenance of primary cilia upon cell cycle re-entry (29130579).

Model organism evidence

Danio rerio (1 reference)

The "toe syndactyly, telecanthus and anogenital and renal malformations" (STAR) syndrome is a rare X-linked dominant inherited kidney ciliopathy caused by CCNQ gene mutations.

PMIDs: 36284407