CDK10

Cilia effects upon perturbation of CDK10

Cilia number / % ciliated:

Increased cilia number

Loss-of-function effect:

Longer cilia

Overexpression effect:

Shorter cilia

Ciliogenesis screen results (3 screens)

• Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.69) PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Ciliopathy associations

• STAR Syndrome

References: PMID:27104747, PMID:28178678, PMID:34369103, PMID:24218572, PMID:29130579

Subcellular localization

basal body

References: PMID:27104747

Functional category

• Ciliary assembly/disassembly
• Actin & cytoskeleton regulation

Function

Interacts with Cyclin M (CycM), encoded by FAM58A to form an active protein kinase. CDK10/CycM is a key repressor of ciliogenesis through the regulation of RhoA and modulation of actin dynamics (27104747). Important for normal regulation of ciliogenesis (29130579). Knocking down CDK10 or CycM resulted in significant increase in the number of ciliated cells, abnormally long cilia and promotion of the maintenance of primary cilia upon cell cycle re-entry (29130579). CDK10/Cyclin M localizes to the base of the primary cilium, concentrated at the mother centriole. Loss of CDK10 or Cyclin M lengthens cilia and increases ciliogenesis, whereas overexpression shortens cilia and decreases ciliogenesis; the complex restrains ciliogenesis through PKN2 phosphorylation and RhoA-dependent actin network formation (PMID 27104747).