CDK2

cyclin dependent kinase 2

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000123374
UniProt:
P24941
OMIM:
116953

Cilia effects upon perturbation of CDK2

Loss-of-function effect:
No effect

Ciliogenesis screen results (4 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-2.30) PMID:41160700

Subcellular localization

basal body, centrosome, cytosol, nucleus

References: PMID:41005307, PMID:30152757, PMID:25613900

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Transcription regulation

Function

Downstream of MCC fate acquisition, Cdk2 is required to initiate and maintain the MCC gene expression program during ciliogenesis. Consistently, MCCs driven to differentiate in the absence of Cdk2 activity fail to undergo ciliogenesis (30152757). CDK2 localized to basal body (25613900).