CDK2
cyclin dependent kinase 2
- Ensembl:
- ENSG00000123374
- UniProt:
- P24941
- OMIM:
- 116953
Cilia effects upon perturbation of CDK2
- Loss-of-function effect:
- No effect
Ciliogenesis screen results (4 screens)
- Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
- Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
- Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-2.30) PMID:41160700
Subcellular localization
basal body, centrosome, cytosol, nucleus
Functional category
- Ciliary assembly/disassembly
- Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
- Actin & cytoskeleton regulation
- Signaling (Hedgehog, GPCRs, ion channels)
- Transcription regulation
Function
Downstream of MCC fate acquisition, Cdk2 is required to initiate and maintain the MCC gene expression program during ciliogenesis. Consistently, MCCs driven to differentiate in the absence of Cdk2 activity fail to undergo ciliogenesis (30152757). CDK2 localized to basal body (25613900).
Model organism evidence
Mus musculus (2 references)
Pyrogallol-Phloroglucinol-6, 6-Bieckol Restored Primary Cilia Length, Which Was Decreased by High-Fat Diet in Visceral Adipose Tissue, and Decreased Adipogenesis.
We use transgenic mice and primary airway epithelial cell culture to show that Cdk2, the kinase responsible for the G1 to S phase transition, is also required in MCCs to initiate motile ciliogenesis.