CDK20
cyclin dependent kinase 20
- Ensembl:
- ENSG00000156345
- UniProt:
- Q8IZL9
- OMIM:
- 610076
- Synonyms:
- CCRK, P42, PNQALRE
Cilia effects upon perturbation of CDK20
- Loss-of-function effect:
- No effect
Ciliogenesis screen results (2 screens)
- Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, casTLE effect=-3.17) PMID:29459680
Phenotypes
- Mouse phenotype:
- cleft palate, anophthalmia, facial cleft, abnormal embryo size, preweaning lethality, complete penetrance, abnormal body wall morphology
- Mouse ciliopathy phenotype:
- abnormal facial morphology, polydactyly
Subcellular localization
cilia, nucleus
Functional category
- Ciliary assembly/disassembly
- T cell biology
- Protein processing & maturation
- Cilia length regulation
Function
Positively and negatively controls both ciliary length and the activity of the Hh pathway, regulates a broad array of processes at levels ranging from the subcellular to the organismal (28817564). Length of wild-type and Ccrk mutant cilia under steady-state (serum starved) conditions measured, although the average cilia lengths were generally similar (2.6 and 3.5 μm, for control and mutant cilia, respectively), there was a broader distribution of cilia lengths in the mutant cells than in the control cells (std. dev. of 0.78 vs. 1.9 for control and mutant cilia, respectively)(PMID: 28817564).
Model organism evidence
The conserved CCRK, RCK, and CDKL5 kinases regulate cilia length in diverse organisms.
Mutations in the Domain of Unknown Function 3719 (DUF3719)-containing protein FAM149B1 have recently been shown to elongate cilia via unknown mechanisms and result in the ciliopathy Joubert syndrome.11 Here we identify XBX-4, a DUF3719-containing protein related to human FAM149B1, as a regulator
BROMI/TBC1D32 together with CCRK/CDK20 and FAM149B1/JBTS36 contributes to intraflagellar transport turnaround involving ICK/CILK1.
PMIDs: 35609210