CDK7

cyclin dependent kinase 7

Tier: Cilia-Associated Genes

Ensembl:: ENSG00000277273
UniProt:: P50613
OMIM:: 601955
Synonyms:: CAK, CAK1, CDKN7, MO15, STK1

Cilia effects upon perturbation of CDK7

Loss-of-function effect:: No effect

Ciliogenesis screen results (3 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

nucleus

References: PMID:21740898

Functional category

Ciliary assembly/disassembly
Viral interactions
Transcription regulation

Function

DYF-18 is an evolutionarily conserved CDK7/CCRK/LF2p-related serine/threonine kinase that is necessary for the proper function of intraflagellar transport, a process critical for cilium biogenesis ( 21740898).

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