CDK7

cyclin dependent kinase 7

Ensembl:
ENSG00000277273, ENSG00000134058
UniProt:
P50613
OMIM:
601955
Synonyms:
CAK, CAK1, CDKN7, MO15, STK1

Cilia effects upon perturbation of CDK7

Loss-of-function effect:
No effect

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia associated gene, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Viral interactions
  • Transcription regulation

Function

DYF-18 is an evolutio rily conserved CDK7/CCRK/LF2p-related serine/threonine ki se that is necessary for the proper function of intraflagellar transport, a process critical for cilium biogenesis ( 21740898).

Model organism evidence

Xenopus (1 reference)

An inducible multiciliated cell line resolves proteome dynamics and identifies CDK7 as a conserved regulator.

PMIDs: 41705999

C. elegans (1 reference)

DYF-18 is an evolutionarily conserved CDK7/CCRK/LF2p-related serine/threonine kinase that is necessary for the proper function of intraflagellar transport, a process critical f

PMIDs: 21740898