CDKL2
cyclin dependent kinase like 2
- Ensembl:
- ENSG00000138769
- UniProt:
- Q92772
- OMIM:
- 603442
- Synonyms:
- KKIAMRE, P56
Cilia effects upon perturbation of CDKL2
- Loss-of-function effect:
- Longer cilia
- Overexpression effect:
- Shorter cilia
Ciliogenesis screen results (4 screens)
- Kim2016: Not Reported
- Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
- Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
Phenotypes
- Mouse phenotype:
- decreased circulating aspartate transamise level, abnormal spleen morphology, decreased circulating potassium level, decreased circulating phosphate level, decreased bone mineral content
Subcellular localization
nucleus, transition zone
Functional category
- Ciliary assembly/disassembly
- Transition zone
Function
C. elegans CDKL-1, most closely related to CDKL1(PMID: 29420175).
Model organism evidence
C. elegans (2 references)
elegans CDKL-1, related to the human CDKL kinase family (CDKL1/CDKL2/CDKL3/CDKL4/CDKL5), specifically controls the length of the proximal segment, a ciliary subdomain conserved in evolution from Tetrahymena motile cilia to C.
Various kinases, including a cyclin-dependent kinase (CDK) family member, regulate the growth and functions of primary cilia, which perform essential roles in signaling and development.