CDKL2

cyclin dependent kinase like 2

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000138769
UniProt:: Q92772
OMIM:: 603442
Synonyms:: KKIAMRE, P56

Cilia effects upon perturbation of CDKL2

Loss-of-function effect:: Longer cilia
Overexpression effect:: Shorter cilia

Ciliogenesis screen results (4 screens)

Kim2016: Not Reported
Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:: decreased circulating aspartate transamise level, abnormal spleen morphology, decreased circulating potassium level, decreased circulating phosphate level, decreased bone mineral content

Subcellular localization

transition zone, Nucleus

References: PMID:29420175

Functional category

Ciliary assembly/disassembly
Transition zone

Function

No CDKL2-specific ciliary evidence. C. elegans has a single CDKL family member, CDKL-1, reported as most closely related to human CDKL1 (PMID 29420175); that finding is evidence for CDKL1, not for CDKL2. Retained on lof_effect = 'Longer cilia' in functional screens.

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