CDKL3

cyclin dependent kinase like 3

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000006837
UniProt:
Q8IVW4
OMIM:
608459
Synonyms:
NKIAMRE

Cilia effects upon perturbation of CDKL3

Loss-of-function effect:
Longer cilia
Overexpression effect:
Shorter cilia

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-7.29) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

transition zone

References: PMID:29420175

Functional category

  • Ciliary assembly/disassembly
  • Neurogenesis & migration
  • Transition zone

Function

No CDKL3-specific ciliary evidence. C. elegans has a single CDKL family member, CDKL-1, reported as most closely related to human CDKL1 (PMID 29420175); that finding is evidence for CDKL1, not for CDKL3. Retained on lof_effect = 'Longer cilia' in functional screens.