CDKL4
cyclin dependent kinase like 4
- Ensembl:
- ENSG00000205111
- UniProt:
- Q5MAI5
Cilia effects upon perturbation of CDKL4
- Loss-of-function effect:
- Longer cilia
- Overexpression effect:
- Shorter cilia
Ciliogenesis screen results (3 screens)
- Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.43) PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
- Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
Phenotypes
- Mouse phenotype:
- increased circulating alkaline phosphatase level
- Mouse ciliopathy phenotype:
- cataract
Subcellular localization
transition zone
Functional category
- Ciliary assembly/disassembly
- Transition zone
Function
C. elegans CDKL-1, most closely related to CDKL1(PMID: 29420175).
Model organism evidence
C. elegans (3 references)
Here we show that CDKL-1 is largely dispensable for regulation of complex cilia structures.
elegans CDKL-1, related to the human CDKL kinase family (CDKL1/CDKL2/CDKL3/CDKL4/CDKL5), specifically controls the length of the proximal segment, a ciliary subdomain conserved in evolution from Tetrahymena motile cilia to C.