CDKN2A

cyclin dependent kinase inhibitor 2A

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000147889
UniProt:
P42771
OMIM:
600160
Synonyms:
ARF, CAI2, CDK4I, CDKN2, CMM2, INK4, INK4A, MLM, MTS1, P14, P14ARF, P16, P16-INK4A, P16INK4A, P19, P19ARF

Cilia effects upon perturbation of CDKN2A

Cilia number / % ciliated:
Decreased cilia number

Ciliogenesis screen results (4 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-3.44) PMID:41160700

Subcellular localization

cilia, cytosol, lysosomes, nucleus, ciliary tip, transition zone

References: PMID:41410385, PMID:41005307, PMID:33574852

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Cell migration & adhesion
  • Cardiac & muscle development
  • Transcription regulation

Function

CDKN2A has localized in cilia.