CDKN2A

cyclin dependent kinase inhibitor 2A

Ensembl:
ENSG00000147889
UniProt:
P42771
OMIM:
600160
Synonyms:
ARF, CAI2, CDK4I, CDKN2, CMM2

Cilia effects upon perturbation of CDKN2A

Cilia number / % ciliated:
Decreased cilia number

Ciliogenesis screen results (4 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-3.44) PMID:41160700

Subcellular localization

cilia, cytosol, lysosomes, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • T cell biology
  • Cell migration & adhesion
  • Cardiac & muscle development
  • Transcription regulation

Function

CDKN2A has localized in cilia.

Model organism evidence

Mus musculus (1 reference)

Assessment of their orientation revealed an absence of primary cilia in the majority of mouse PCS chondrocytes, which was corroborated in human PCSs.

PMIDs: 25644707