CDKN2B

Cilia effects upon perturbation of CDKN2B

Ciliogenesis screen results (3 screens)

• Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-7.16) PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia associated gene, cytosol, nucleus

Functional category

• Ciliary assembly/disassembly
• Actin & cytoskeleton regulation
• T cell biology
• Neurogenesis & migration
• Signaling (Hedgehog, GPCRs, ion channels)
• Transcription regulation

Function

MST1/2 has a noncanonical function: regulation of microtubule stability/dy mics. Loss of MST1/2 or its target(s) NDR1/2 destabilizes kinetochore-microtubule attachment during mitosis ( 20171103 , 19327996). MST1/2 binds and phosphorylates AURKA, leading to dissociation of the AURKA/HDAC6 cilia-disassembly complex, and MST1/2-SAV1 associates with the NPHP transition-zone complex, promoting ciliary localization of multiple ciliary cargoes ( 25367221). CDKN2B gene is enrolled in the Transforming growth factor beta receptor signaling pathway (GO:0007179) (41005307).