CDON

cell adhesion associated, oncogene regulated

Tier: Cilia-Associated Genes

Ensembl:
ENSG00000064309
UniProt:
Q4KMG0
OMIM:
608707
Synonyms:
CDO, CDON1, IHOG, ORCAM

Cilia effects upon perturbation of CDON

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-6.89) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
preweaning lethality, incomplete penetrance

Ciliopathy associations

  • Holoprosencephaly

References: PMID:21802063

Subcellular localization

lysosomes

References: PMID:30485816, PMID:39239564

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Neurogenesis & migration
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development

Function

At the far periphery, ciliary margin (CM) markers Otx1 and Cdon together with Wnt3a and Fzd1 were ectopically upregulated, whereas neuroreti l progenitor markers Sox2, Notch1, and Otx2 were absent or reduced ( 30485816). CDON morphants displayed slightly shorter cilia than controls, and the number of cilia was also decreased in CDON morphants (39239564)