CDT1

chromatin licensing and DNA replication factor 1

Tier: Cilia-Associated Genes

Ensembl:
ENSG00000167513
UniProt:
Q9H211
OMIM:
605525
Synonyms:
DUP, RIS2

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.11) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, neg_rank=507, lfc=-2.86) PMID:30270045

Subcellular localization

cytosol, nucleus

References: PMID:23516378

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation

Function

Depletion of ORC1, ORC4, ORC6, CDT1 and CDC6 resulted in dramatically impaired cilia formation similar to ORC1-deficient patient cells ( 23516378).