CELSR1

cadherin EGF LAG seven-pass G-type receptor 1

Tier: Cilia-Associated Genes

Ensembl:: ENSG00000075275
UniProt:: Q9NYQ6
OMIM:: 604523
Synonyms:: ADGRC1, CDHF9, FMI2, HFMI2, ME2

Ciliogenesis screen results (3 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.49) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

nucleus

References: PMID:25406397

Functional category

Ciliary assembly/disassembly
Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
Actin & cytoskeleton regulation
Signaling (Hedgehog, GPCRs, ion channels)

Function

In Celsr1-deficient mice, the ciliary motion is not orchestrated along the ovary-uterus axis and the transport ability of beating cilia is impaired ( 25406397).

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